Cialis - is a drug, used for treatment of erectile dysfunction (erection disorders). It causes relaxation of penile arteries and increases blood flow to the tissues of the penis, resulting in and an erection. Latin name: Cialis. The composition and form: Cialis tablets, coated tablets, for 1, 2, 4, 8 pcs. in the package. 1 tablet contains 20 mg of Cialis Tadalafil. Active substance: Tadalafil.
Properties / actions:
Cialis (Tadalafil) is an effective, reversible, selective inhibitor of specific phosphodiesterase type 5 (PDE-5), cyclic guanosine monophosphate (cGMP). When sexual stimulation causes local release of nitric oxide, inhibition of PDE-5 tadalafilom leads to increased levels of cGMP in the cavernous body of penis. The result is relaxation of smooth muscles of arteries and blood flow to the tissues of the penis that causes an erection. Tadalafil has no effect in the absence of sexual stimulation. Studies in vitro have shown that tadalafil is a selective PDE-5 inhibitor. PDE-5 is an enzyme found in smooth muscles of cavernous bodies in the vascular smooth muscles of internal organs, skeletal muscle, platelets, kidney, lung and cerebellum. Effects of tadalafil for PDE-5 are more active than other phosphodiesterase. Tadalafil is 10 000 times more potent against PDE-5 than for FDE1, FDE2 and FDE4, which are located in the heart, brain, blood vessels, liver and other organs. Tadalafil 10 000 times more active blocks PDE-5 than FDE3 - an enzyme that is found in the heart and blood vessels. This selectivity against PDE-5 compared with FDEZ is important, because FDEZ is an enzyme involved in the reduction of the heart muscle. In addition, tadalafil about 700 times more active against PDE-5 than in respect FDE6 found in the retina and. Tadalafil has also shown the action of 10 000 times more potent against PDE-5 compared with its effect on FDE7 - FDE10. Tadalafil improves erection and the possibility of successful sexual intercourse. The drug acts within 36 hours. The effect is manifested even after 16 minutes of ingestion in the presence of sexual stimulation. Tadalafil in healthy individuals does not cause significant change in systolic and diastolic blood pressure compared with placebo in the supine position (mean maximum reduction is 1, 6 / 0, 8 mm Hg. St., Respectively) and standing (mean maximum reduction is 0, 2 / 4, 6 mm Hg. Art., respectively). Tadalafil does not cause significant change in heart rate. In the study of tadalafil in men in the 10 mg / day revealed no clinically significant effect of the drug on the number and concentration of sperm motility and sperm morphology.
After taking Cialis tadalafil is rapidly absorbed by mouth. The average maximum concentration (C max) in plasma is reached after an average of 2 hours after ingestion.
The speed and extent of absorption of tadalafil is not dependent on food intake, and the drug Cialis can be taken irrespective of meals. Hours (morning or evening) had no clinically significant effect on the rate and extent of absorption.
The pharmacokinetics of tadalafil in patients with erectile dysfunction is similar to the pharmacokinetics of the drug in patients without erectile dysfunction.
The average volume of distribution is about 63 liters, which indicates that Tadalafil is distributed in the tissues of the body. At therapeutic concentrations, 94% of tadalafil in plasma is associated with protein-mi. Protein binding is not altered by impaired renal function.
In healthy persons less than 0,% 0005 administered dose was found in semen. You can buy cialis online.
Hence, one can hardly assume that this metabolite in the observed concentrations is clinically significant. In healthy individuals mean clearance of tadalafil ingestion of 2, 5 l / h, and the average half-life - 17, 5 hours. Tadalafil is derived mainly as inactive metabolites, mainly with feces (about 61% of the dose) and to a lesser extent, with urine (about 36% of the dose).